Wiscoy Creek is a stream, approximately 15 miles long, in western New York in the United States. It is a tributary of the Genesee River and joins that river in the town of Hume in northern Allegany County. The Wiscoy originates from two branches in Wyoming County. The North Branch begins in the township of Wethersfield and the West Branch originates in the township of Eagle. The branches meet in the hamlet of Bliss and flow southeast through the village of Pike. The creek's name is derived from the Seneca tribe word meaning five falls creek.